Irradiated tumor cells present calreticulin at their surface and release DAMPs, such as adenosine-5-triphosphate (ATP) and high-mobility group protein box 1 (HMGB1) [34], that promote phagocytosis in DCs; ATP recruits DCs; HMGB1 activates DCs and CTLs. The gene discussed is HMGB1; the disease is neoplasm.