However, the increased piR-18849 expression was associated with poorly differentiated tumors and the greater presence of metastasis in lymph nodes; meanwhile, the higher expression of piR-19521 was associated with poorly differentiated CRC tumors, suggesting the probable usefulness of piR-18849 and piR-19521 as prognostic biomarkers for CRC patients [69]. This evidence concerns the gene PIR and colorectal carcinoma.