GC is a multifactorial disease, where certain environmental and genetic factors can increase the risk of developing this neoplasm, e.g., Helicobacter pylori infection (the most important risk factor), Epstein-Barr virus (EBV) infection, diet, alcohol consumption, smoking, and family history of GC (mainly linked to CDH1 gene alterations) [77]. Here, CDH1 is linked to gastric cancer.