Consistently, WD-fed alb-myctg mice 24 weeks of exhibited stronger hepatic inflammation (CD45 positive cells) (Figure 5E and Figure S11F) and extensive hepatic fibrosis, assessed by SR staining (Figure 5F and Figure S11G) and αSMA (Figure 5G, middle, Figure S11H,I) expression. Here, ACTA1 is linked to Hepatic fibrosis.