HIF1A and neoplasm: Currently, the following are being investigated and refined: targeting glutamine metabolism in tumor cells [106,246], arginine metabolism in myeloid cells [247], tryptophan metabolism in the TME [248], lipid metabolism in both, tumor [207] and immune cell populations [249] and disruption of signaling pathways activated by nutrient availability and oxygen content (i.e., mTORC1 [250,251], AMPK [252], HIF-1α [234,253,254]).