Inactivation of chromatin remodeling genes are frequently observed in MALT lymphomas, with the most common mutated genes being TET2, KMT2D, CREBBP, TBL1X1, KMT2C, MT2C, EP300, among others [37,145,156,157,159,167,169,176] (Figure 1 and Supplemental Table S1). The gene discussed is EP300; the disease is MALT lymphoma.