The t(14;18)(q32;q21) is the second most common among all balanced translocations in MALT lymphoma and brings the MALT1 gene under the transcriptional control of the IgG enhancer, then MALT1 expression is deregulated fostering NF-kB activation [67,71,100,101,102,103]. The gene discussed is MALT1; the disease is MALT lymphoma.