CDH1 and Familial gastric cancer: Chemoprevention of HDGC can be achieved by either targeting the early stage T1a SRCC foci before they have acquired the capacity for invasion beyond the muscularis mucosae, or by reducing the risk of epigenetic silencing of the second CDH1 allele, leading to complete loss of E-cadherin expression and migration of epithelial cells into the lamina propria.