ERBB2 and breast cancer: Given that canonical signaling analysis in IPA identified the inhibition of HER-2 signaling in breast cancer, the Analysis Match function in IPA was used to identify databases in the public domain that have been annotated in the IPA knowledge database for patterns of expression consistent with the effects of 4-oxo-DHA on MDAMB468, a poor prognosis molecular subtype of breast cancer with metastatic potential.