CDK4 and acute myeloid leukemia: Furthermore, the efficacy of combination therapy is suggested by studies in acute myeloid leukemia (AML), i.e., the inhibition of CDK4/6 by abemaciclib or palbociclib and autophagy by CQ-suppressed cell growth and induced apoptosis in t(8;12) AML cells [123] and in a mouse xenograft model of t(8;12) AML [124] (Table 1).