Since obtaining both fresh human tissues of lung adenocarcinoma and of a non-involved adjacent tissue from the same patient is hard to achieve, we used immunohistochemistry (IHC) to investigate TMEM45A expression in 17 lung adenocarcinoma patients (patients 1–17) versus 3 nontumorous patients (patients 18–20) with pneumothorax (Figure 9 and Supplementary Materials Table S5). Here, TMEM45A is linked to pneumothorax.