ITGAM and B-cell chronic lymphocytic leukemia: For example, trabectedin exhibited antileukemic effect in a xenotransplanted CLL murine model, and was related to a significant reduction in CD11b+F4/80+ TAMs in the spleen and peritoneal exudate, with selective depletion of CD11b+CD206+ M2-like protumor TAMs in the peritoneal exudate [78].