The percentage of the degranulating cells (CD107a+) was remarkably increased in NK (CD56+CD3−) cells and CD8+ T cells after PBLs from FL patients were co-cultured for 14 days with autologous apoptotic lymphoma cell-loaded IFN-DCs, exhibited perforin-containing granules at the cell-cell contact site of CD56+ and CD8+ lymphocytes. The gene discussed is CD8A; the disease is lymphoma.