Using histologically different NHL cell lines, such as DoHH-2, SU-DHL-4 and SU-DHL-6, Zappasodi and Di Nicola et al. demonstrated that heat shock, γ-ray, or ultraviolet C ray, or their combined use increased surface translocation of CRT and cellular release of the chromatin-binding protein high-mobility group box 1 (HMGB1) and adenosine triphosphate compared with doxorubicin, a well-known chemotherapeutic agent that causes ICD and is included in a combination chemotherapy regimens, such as CHOP, and is frequently used as treatment for NHL patients. This evidence concerns the gene CALR and non-Hodgkin lymphoma.