Then, OSCC patient-derived stromal cell xenografts (PDSXs) by co-transplanting the stromal cells isolated from patients with different OSCC subtypes: SCC and VSCC with OSCC cell line (HSC-2) to the BMT nude mice, and we evaluated the infiltration of BMDCs and the expression of MMP9 and MMP2 in the invasion front line of the tumor. This evidence concerns the gene MMP2 and neoplasm.