CDKN1A and neoplasm: In addition, the stratification of the tumor samples into CMS1 and CMS4 allowed us to further investigate the genes characteristic for the molecular signature of HCT116 p21-/- cells (i.e., the signature of the 67 genes defined above, included in Supplementary Table S1, which can be considered to be involved in the switch between CMS1 and CMS4.