The complete results corresponding to all 67 genes of our refined signature were included in Supplementary Table S1 and showed a clear correlation of genes upregulated in HCT116 p21-/- cells and CRC subtype CMS4 (all 25 of the upregulated genes showed a higher expression in CMS4), while genes downregulated in the HCT116 p21-/- cells were associated to the CRC subtype CMS1 (40 out of 42 genes showed a higher expression in CMS1). The gene discussed is CDKN1A; the disease is colorectal carcinoma.