Overall, aside from the expression of ACKR3 and CXCR4 in glioma cells as well as in multiple cell subtypes from the TME, it appears that cell components of the neighboring healthy brain tissue require ACKR3 and CXCR4 for their maintenance and function, which could complexify their targeting in GBM therapy. This evidence concerns the gene CXCR4 and central nervous system cancer.