Another phase I/II trial (NCT01977677), aiming at studying the safety and efficacy of the CXCR4 inhibitor plerixafor, after chemo/radiotherapy with the chemotherapeutic agent temozolomide (TMZ), suggests CXCR4-targeting as beneficial for patient survival and local control of tumor recurrence [35]. The gene discussed is CXCR4; the disease is neoplasm.