Indeed, immune parameters such as increased levels of B-cell activating cytokines including interleukin (IL)10, IL6 and B-cell activating factor (BAFF), or serum markers associated with B-cell activation (CRP, sCD30, sCD27, sCD23, and free immunoglobulin light chains), positively correlate with the incidence of cHL [8,9,10,11]. Here, TNFSF13B is linked to classic Hodgkin lymphoma.