Our results in patients with CRC aged 70 or older identified IADL, creatinine clearance, weight loss and the MAX2 index as risk factors for grade 3–4 toxicity; clinical stage, weight loss, creatinine clearance, albumin and Charlson comorbidity score for UH; and clinical stage, weight loss, ADL and hemoglobin for ED. The gene discussed is ALB; the disease is colorectal carcinoma.