ITGAM and neoplasm: An interaction between immune response and radiotherapy has been experimentally proven, in which radiation-mediated leukocyte infiltration can be driven by changes in leukocyte extravasation, inducing infiltration of a range of leukocytes such as: regulatory T cells (Tregs), cells Effector cells, natural killer (NK) cells, CD11b + cells such as myeloid-derived suppressor cells (MDSCs), and macrophage-associated tumor cells (TAMs).