IL2 and neoplasm: Indeed, PD-L1_1 plus ID-1 treatment showed potent effects on tumor cells lysis, reaching 100% of lysis in co-cultures of MDA-MB-231 cells and inducing a higher secretion of IL-2 and IFN-γ with respect to atezolizumab and ipilimumab, but exerted opposite effects on cardiomyocytes.