VEGFA and glioblastoma: In 2009, Bevacizumab (Avastin®, Genentech/Roche), a monoclonal antibody against human vascular endothelial growth factor (VEGF), the most characterized proangiogenic factor, entered clinical practice thanks to quick US Food and Drug Administration (FDA) approval, as a monotherapy for the treatment of patients with recurrent glioblastoma.