PTGS2 and breast cancer: Several time-dependent effects were observed in HUVECs and breast cancer or prostate line co-cultures: in the first 6 h, some genes indicating a pro-angiogenic effect, such as VEGF-A, prostaglandin-endoperoxide synthase 2 (PTGS2), which encodes COX-2, coagulation factor III, thromboplastin (FIII) and ADAM Metallopeptidase with Thrombospondin Type 1 Motif 1 (ADAMTS1), were over-expressed.