Given the indispensable function of BRCA1 in maintaining genome stability, it is thought that DNA damage associated with BRCA1 loss results in random mutations in the genome, which inactivate tumor suppressor genes, such as TP53 or activate oncogenes such as MYC, which, through natural selection, promote tumor formation and metastasis [28,39,40,41]. The gene discussed is TP53; the disease is neoplasm.