CD274 and non-small cell lung carcinoma: Targeted therapy and immunotherapy have drastically changed the prognosis of patients treated for an advanced/metastatic NSCLC to the point that, nowadays, they have become the standard of care in the front-line setting in patients with targetable genetic alterations and no contraindications to PD-1/PD-L1 inhibitors [8,9,10,11,12,13,14].