At the time of ICI-induced IDDM diagnosis, 20 (59%) patients were receiving an anti-PD1/PD-L1 monoclonal antibody in monotherapy, 9 (26%) patients were being treated with an anti-PD1/PD-L1 in combination with an anti-CTLA4 antibody, 3 (9%) were receiving anti-PD1/PD-L1 antibodies combined with other agents, and the remaining 2 (6%) patients were being treated in anti-PD1/PD-L1-based double-blind randomized clinical trials (i.e., anti-PD1/PD-L1 with another agent or placebo). The gene discussed is CTLA4; the disease is type 1 diabetes mellitus.