Indeed, we have also observed tumor-induced increases in the expression of Nrf2 (nuclear factor erythroid 2-related factor 2), p62 (Sequestosome 1), Gadd34 (Ppp1r15a gene: protein phosphatase 1 regulatory subunit 15A), and Bnip3 (BCL2 interacting protein 3), which were, however, inconsistent between models (Supplemental Figure S3). The gene discussed is BNIP3; the disease is neoplasm.