In addition, tumor vascularization and endothelial permeability are tightly linked with inflammation [35] and may influence circulating cachexia mediators, yet the expression of vascularization marker genes (Epas1, Tie2, Vegfr2, Pecam1 (CD31) [36] was not different between young and aged mice across all experiments (data not shown). Here, TEK is linked to Cachexia.