CXCR4 and neoplasm: For example, the depletion of CXCL12-producing fibroblast activation protein-α (FAP+) CAFs allowed for immunological control of tumor growth in KPC (Pdx1Cre, KrasLSL-G12D, and Trp53LSL-R172H) mice and a combination of CAF depletion or CXCR4 inhibition with AMD3100 with anti–PD-L1 resulted in tumor regressions [65,66].