In a study similar to ours, where WES was performed in primary tumours of 51 HPV+ OPSCC, of which 35 did not recur, and 16 recurred, and in 33 primaries of HPV− oral cavity cancers and OPSCC, KMT2D was found to be the most commonly mutated gene in both primary (14%) and recurrent (42%) HPV+ OPSCC [22]. Here, KMT2D is linked to neoplasm.