This investigation studied the expressions of c-myc, c-myb, c-ras-Ha, c-erbB-1 and c-erb-B-2 proto-oncogenes in NSCLC and observed their detectable abnormalities in adenocarcinomas (ten out of sixteen) and large-cell cancers (two out of two). This evidence concerns the gene MYC and non-small cell lung carcinoma.