However, in the same study, the authors detected RIPK1 expression in biliary epithelial cells of cystically dilated bile ducts of patients with Caroli disease/syndrome (with additional congenital hepatic fibrosis) [7], suggesting that the regulation of JNK1/RIPK1 signaling could be a potential therapeutic avenue for PLD patients. This evidence concerns the gene MAPK8 and Hepatic fibrosis.