A number of blood and tumor markers have been evaluated in clinical studies, such as PD-L1 expression in the tumor cells (PD-L1TC), tumor mutational burden (TMB), neutrophil to lymphocyte ratio (NLR), the presence of tumor-infiltrating lymphocytes (TIL) (such as CD8+ T cells), or a specific immune gene signature correlating with response [4,5,6,7,8]. The gene discussed is CD274; the disease is neoplasm.