Several immuno-PET tracers’ [94,95,96,97,98,99,100,101,106,107] target membrane proteins whose expression is altered in glioblastoma including the Epidermal Growth Factor Receptor (EGFR), Delta-Like Ligand 4 (DLL4), Ephrin type-A receptor 2 (EPHA2), Cluster of differentiation 47 (CD47), the AC133 antigen, and the Membrane-type 1 matrix metalloproteinase (MT1-MMP/MMP14) (Figure 5). The gene discussed is PROM1; the disease is glioblastoma.