The investigated multi-modal data for glioma assessment comprised TSPO ([18F]GE180, S-N,N-diethyl-9-(2-[18F]fluoroethyl)-5methoxy-2,3,4,9-tetrahydro-1H-carbazole-4-carboxamide) PET, amino acid ([18F]FET, O-(2-[18F]fluoroethyl)-L-tyrosine) PET, and T1-weighted MRI, where voxels from contrast enhanced relative to native T1-weighted MRI images were used as signature of BBB integrity [2]. Here, TSPO is linked to central nervous system cancer.