BCL2L1 and Thrombocytopenia: Navitoclax entered clinical trials in 2005, and although its clinical development has been hindered by dose-dependent thrombocytopenia, related to the inhibition of BCL-XL on platelets, it continues to be evaluated for myelofibrosis, as well as a range of advanced solid tumors, primarily in combination with tyrosine kinase inhibitors [109,110].