Palcitoclax (APG-1252), a novel dual BCL-2/BCL-XL inhibitor, has also been designed to reduce platelet toxicity, and a ‘3+3’ design phase 1 escalation study revealed favorable toxicity and anti-cancer activity with 3 out of 36 evaluable patients achieving a partial response, including in one patient with neuroendocrine prostate cancer [153]. The gene discussed is BCL2L1; the disease is cancer.