Interestingly, DT2216 has been shown to induce apoptosis in tumor-infiltrating regulatory T-cells, and activate tumor infiltrating CD8+ cells, resulting in suppression of tumor growth in immunocompetent, but not-immunodeficient, mouse models, indicating that targeting BCL-XL may be a promising strategy in cancer immunotherapy [150]. The gene discussed is BCL2L1; the disease is neoplasm.