EP300 and acute myeloid leukemia: This is strongly supported by genome-wide ChIP studies showing that MYB, C/EBPβ, and p300 (together with other myeloid transcription factors) co-localize at many genomic sites in AML cells which correspond to cis-acting transcriptional control regions of genes, such as MYC and GFI1, which are expressed in these cells [65].