MYB and acute lymphoblastic leukemia: Genomic rearrangements of human MYB (gene) and mutations that create de novo MYB binding sites in transcriptional control regions of the TAL1 and LMO2 oncogenes have been detected in acute lymphoid leukemia, indicating that MYB plays a causal role in the development of these leukemias [19,20,21,22,23].