Moreover, all of the clinical parameters widely used to estimate the aggressiveness of tumors, including tumor stage, status of lymph node metastasis, and grade of differentiation were significantly associated with higher methylation of the INA, NHLH2, and THBS4 candidate loci in both the allRCC and ccRCC groups (Table 3a,b). This evidence concerns the gene INA and nonpapillary renal cell carcinoma.