Our supervised classification analysis of single CpG site methylation information using independent training and test data subsets and random forest analysis revealed that methylation information for a subset of 10 candidate loci from the total of 18 INA, NHLH2, and THBS4 annotated CpG sites already permits the identification of tissue samples with a metastatic disease state in an otherwise unknown tissue cohort with good accuracy. Here, THBS4 is linked to metastatic neoplasm.