THBS4 and metastatic neoplasm: Methylation of the INA, NHLH2, and THBS4 loci was also measured in a subset of 136–142 primary tumor tissues free of lymph node or distant metastasis and a total of 202 cancer metastatic tissues isolated from 100 renal cell cancer patients suffering from metachronous metastatic disease (Figure 4b, Table 4).