In addition, the expression of key genes in the TNF-α/NF-κB signaling, including NFKB1 (p50), RelA (p65), TNFRSF1A (TNFR1), TNFR1-associated death domain protein (TRADD), and TNF receptor-associated factor 2 (TRAF2), was examined in the cell lines and tumor tissues of EBV-associated cancers. The gene discussed is NFKB1; the disease is cancer.