RB1 and acute lymphoblastic leukemia: Other recurrent focal CNAs in near-haploid B-ALL include CDKN2A/B at 9p21.3 (22% of patients), a histone cluster at 6p22 (19% of patients), IKZF3/Aiolos at 17q12 (13% of patients), RB1 at 13q14.2 (9% of patients) and PAX5 at 9p13.2 (7% of patients) [30].