Instead, IKZF2/Helios loss at 2q34 is the most recurrent alteration involving genes associated with B-cell differentiation (53% in children and 36% in adults), being much more frequently observed in low-hypodiploid B-ALL than in any other B-ALL subtype, including near-haploid ALL (Table 4). This evidence concerns the gene IKZF2 and acute lymphoblastic leukemia.