In addition, high levels of TNF and IL-10 were measured in the serum of high risk groups of CLL patients [23] with a median of 5.04 pg/mL for IL-10 compared to zero for healthy donors [27,37,38] and 17 to 34 pg/mL for TNF, level for healthy donors being at 5 pg/mL [39]. Here, TNF is linked to B-cell chronic lymphocytic leukemia.