CD40LG and Niemann-Pick disease, type C1: 7-KC is a main constituent of oxLDL and oxLDL neutralization by increasing plasma IgM antibodies of the E06 idiotype strongly trended toward a decrease in splenomegaly (P = 0.06) in a previous study employing the same mouse model of NPC1 disease, where this treatment also improved hepatic inflammation (28).