Furthermore, we recently demonstrated that a subpopulation of neutrophils in critically ill COVID-19 patients undergoes TNF-α-driven necroptosis [54], with concomitant release of various damage associated molecular patterns and alarmins, such as S100A8/A9, which are known to contribute to pathological damage [22,55,56]. This evidence concerns the gene IGKV1D-22 and COVID-19.