NO acts as a cytotoxic agent in pathological processes, specificallyin inflammatory disorders.37 In this sense,numerous scientific articles have shown that NO production is elevatedin chronic inflammatory diseases, such as diabetes,38 atherosclerosis,39 or multiplesclerosis.40 The iNOS protein is mainlyresponsible for the production of cellular NO;24 in fact, its inhibition may be a therapeutic target ininflammatory diseases.41 In our study,we observed that H2 and H3 peptides reduced NO and iNOS productionin LPS-stimulated HepG2 cells. Here, NOS2 is linked to atherosclerosis.