The FXR activated by GW4064 inhibited the migration of breast tumour CAFs by decreasing integrin-linked kinase (ILK), Ras homolog family member A (RhoA)-C, cell division control protein 42 homolog (Cdc42), Ras-related C3 botulinum toxin substrate 1 (Rac1)-3, myosin light chain (MLC) and phosphorylated Akt proteins, where the blocking of FXR by guggulsterone resulted in decreased effect of GW4064 [105]. The gene discussed is NR1H4; the disease is breast neoplasm.