HNF4A and neoplasm: Further, the activation of FXR by GW4064 leads to the deactivation of oncogene gankyrin (Gank) and induction of tumour suppressor proteins such as p53, CCAAT/enhancer binding protein (C/EBP)α, and hepatocyte nuclear factor 4α (HNF4α), preventing the development of tumour in a mouse model [133].