NR1H4 and breast cancer: Further, the treatment with GW4064 in breast cancer cells increase apoptosis through nuclear condensation and stimulation of FXR target genes such as SHP, multi-drug resistance-associated protein (MRP)-2 and ileal bile acid-binding protein (IBABP) while repressing MDR3, MRP1, solute carrier family 7 member 5 (SLC7A5), aromatase (CYP19), and growth arrest and DNA damage-inducible (GADD) proteins [112].