Similarly, inhibition of Gank as well as induction of C/EBPβ, HDAC1 proteins and other tumour suppressor proteins, through activation of FXR by CDCA and GW4064, inhibited liver carcinogenesis, while, FXR knockout mouse developed tumour with elevated Gank and decreased C/EBPβ levels [138]. This evidence concerns the gene NR1H4 and neoplasm.