Moreover, the activation of FXR by GW4064 or its overexpression inhibits cell proliferation via suppression of Src (Tyr416)-mediated p-EGFR (Tyr845) and its target p- ERK1/2 which leads to an increase in apoptosis in vitro as well as decreased tumour growth in vivo. The gene discussed is NR1H4; the disease is neoplasm.