Further, a study reported that the activation of FXR by GW4064 and CDCA resulted in apoptosis by sensitizing the cancer cells to cisplatin by inhibiting phosphorylated signal transducer and activator of transcription 3 (pSTAT3) and B-cell lymphoma-extra large (Bcl-xL) expressions through FXR-induced SHP cascades [114]. This evidence concerns the gene NR1H4 and cancer.