TIMP2 and neoplasm: Besides, the FXR deficient mouse with elevated liver injury and tumour progression, showed an increase in fibrosis promoting proteins such as collagen, TNF-α, IL-1β, IL-6, MMPs-(2, − 3 & -9), tissue inhibitor of metalloproteinases 2 (TIMP-2), transforming growth factor (TGF)-β1 and α-smooth muscle actin (Sma-α) [146].