As proof-of-concept, authors showed that, in orthotopic tumor xenograft models, TEL+ and ALT+ tumors could be discriminated through combinations of 1H- and hyperpolarized 13C-magnetic resonance spectroscopy-detectable metabolic signatures, opening interesting perspectives for the future non-invasive diagnosis of patients with low-grade oligodendrogliomas or low-grade astrocytomas [17]. This evidence concerns the gene ETV6 and neoplasm.