Among these proteins, U1–70K (Snrnp70) is the target of self-reactive B cells and T cells in several rheumatic diseases [38], Ptbp1 is essential for B cell ontogeny and B cell receptor (BCR)-mediated antibody production [44, 45], HnrnpL involved in the regulation of TNF α gene transcription [48]. Here, TNF is linked to rheumatic disorder.