As shown in Table 3, the literature research showed that most of these proteins are related to the abnormal proliferation and metastasis of tumor cells, but few of them have been studied in RA, several proteins were firstly reported associated with RA, such as Pura, Nfic, Ruvbl1, Snrpd3, U2af2, Srrm2, Srsf7, Elavl1, Hnrnph1, Wars, Yars, Bzw2, Mcts1, Eif4b, Ctsh, Lamp1, Dpp7, Ptges3, Cdc37 and Septin9. This evidence concerns the gene RUVBL1 and neoplasm.