Among them, Ribosomal proteins were upregulated in the synovial membranes of female patients with Osteoarthritis [55], Carhsp1 can regulate the stability of TNF -α mRNA [57], they might be associated with RA, no other proteins, such as Wars, Yars, Bzw2, Mcts1 and Eif4b were reported in RA. This evidence concerns the gene MCTS1 and osteoarthritis.