Vascular epidermal growth factor (VEGF), an angiogenetic factor on the cell membrane and one of the most well-studied targets for solid tumors [102], was a candidate for the targeted therapy of SCCHN, but the phase 3 trial of the anti-VEGF antibody bevacizumab did not show a survival benefit for SCCHN patients [103]. Here, VEGFA is linked to head and neck squamous cell carcinoma.