EGFR-targeted antibodies including cetuximab are thought to bind with the EGFRs on the membrane of the tumor cells and have shown antitumor activity, but clinical analyses indicated that the amplification of the EGFRs in tumor membranes, at least those revealed by immunohistochemistry (IHC), is not a predictive factor of the antibody’s effectiveness. This evidence concerns the gene EGFR and neoplasm.