Growing evidence indicates that ChREBP plays an essential role in tumorigenesis and progress of cancer; for instance, interference of ChREBP in HCC and CRC cells results in decreased proliferative and tumorigenic potential in vivo, accompanied by a metabolic switch from aerobic glycolysis towards OXPHOS, attenuated lipogenesis, and nucleotide synthesis [129]. The gene discussed is MLXIPL; the disease is hepatocellular carcinoma.