SDHB and gastrointestinal stromal tumor: Additionally, mutations or deletion of SDH have been observed in gastrointestinal stromal tumors (GIST), renal tumors, thyroid tumors, neuroblastoma, and testicular seminoma, hereditary paragangliomas (hPGLs), OVC, and pheochromocytomas (PCCs), implicating its importance in multiple cancers [85].