LDHA and familial pancreatic carcinoma: For instance, LDHA knockdown suppresses tumor growth and tumorigenicity in ESCC or k-Ras-induced NSCLC mouse model, and LDHA-knockdown HCC cells show increased apoptosis; and inhibition of LDHA by FX11 dramatically reduces ATP levels, then induces significant oxidative stress and inhibits the progression of human lymphoma as well as pancreatic cancer xenografts [71].