FOXO1 and breast carcinoma: For instance, miR-27a and miR-96 were identified as regulators of FOXO1 expression together with miR-182, and were highly expressed in MCF-7 and MDA-MB-231 breast cancer cells, causing down-regulation of FOXO1 protein levels which contributed to maintenance of a proliferative state while impairing apoptotic responses [79].