HK2 and breast cancer: In hypoxic breast cancer cells, oxidative stress-induced overexpression of miR-181c blocked HIF-1α accumulation and diminished hypoxia-inducible levels of glycolysis enzymes, including glycolysis-associated glucose transporter-1 (GLUT1), hexokinase 2 (HK2), PDK1, and lactate dehydrogenase A (LDHA) [153].