For example, overexpression of miR-124 was found to inhibit the expression of SIRT1 and thus promoted the generation of ROS, which induced miR-124 binding to the 3’UTR region of STAT3 and inhibited the expression of STAT3 proteins, resulting in reduced cell proliferation in HCC cells [214, 215]. Here, STAT3 is linked to hepatocellular carcinoma.