TP53 and non-small cell lung carcinoma: In NSCLC cells, treatment with marine actinomycetes derived 1-hydroxy-1-norresistomycin (HNM) increased ROS generation in mitochondria and upregulated the p53 mediated transcriptional regulation of two lncRNAs (LED and LOC285194), leading to cell cycle arrest and subsequent apoptosis [93].