miR-30, a miRNA frequently overexpressed in human cancers, has been found to disrupt senescence and promote cancer by suppressing 2 targets, CHD7 (a transcriptional coactivator essential for induction of p16INK4A) and TNRC6A (a miRNA machinery component required for repairing oxidative stress-induced DNA damage) [75]. The gene discussed is CHD7; the disease is cancer.