ITGB8 and central nervous system cancer: Further study found that circ-TTBK2 was a sponge of miR-761 to modulate ITGB8, and knockdown of circ-TTBK2 induced lipid ROS production, which promoted ferroptosis and retarded cell proliferation, invasion in glioma cells, suggesting a potential biomarker for clinical glioma treatment [269].