GAS5 and colorectal cancer: For example, lncRNA GAS5 (growth arrest specific 5) was found to directly interact with the WW domain of YAP to facilitate translocation of endogenous YAP from the nucleus to the cytoplasm, thus promoting phosphorylation and subsequently ubiquitin-mediated degradation of YAP to inhibit colorectal cancer (CRC) progression in vitro and in vivo [25].