Tumour-derived EVs that contain proteins like epiregulin [30] and CEMIP [31] or RNA fragments such as mRNAs [32] and microRNAs (miR-105 [33], miR-25-3p [34], miR-181c [35]) directly or indirectly promote vascular permeability and angiogenesis in the PMN via the upregulation of proangiogenic factors and the modulation of tight junction proteins in endothelial cells. Here, CEMIP is linked to neoplasm.