Tumour-evoked regulatory B cells (tBregs) that are actively generated by normal B cells in response to the direct effects of tumour-derived factors, induce the conversion of metastasis-supporting FoxP3+ Tregs from nonregulatory CD4+ T cells [302] and activate the regulatory function of both the monocyte and granulocyte subpopulations of MDSCs [303], both of which depend on TGF-β signalling, thus inducing an immunosuppressive environment in PMN to support lung metastasis. This evidence concerns the gene CD4 and neoplasm.