Fogelgren et al. [137] suggested that the fibronectin matrix may provide a specific microenvironment to regulate LOX catalytic activity and Erler et al. [74] demonstrated that in the case of lung metastasis, after secreted by primary breast tumours, LOX co-localized with fibronectin within the domain of the PMN where it catalyses crosslink collagen IV in the lung basement membrane. The gene discussed is FN1; the disease is breast neoplasm.