As a part of the homing cascade, SDF-1 from MSCs and their terminal differentiation, osteoblasts, interacts with its receptor CXCR4, which is highly expressed by bone metastasizing lineages like breast and prostate, facilitating tumour cells to colonize and survive in the bone microenvironment [105, 112, 113]. Here, CXCL12 is linked to neoplasm.