Numerous studies have documented that signalling pathways in endothelial cells such as STAT3 signalling [60], Notch1 signalling [61], calcineurin-NFAT signalling [62] and CCR2/CCL2 signalling [42, 63] modulate the expression of cytokines, chemokines and adhesion molecules, which are, at least in part, responsible for adhesion and invasion of tumour cells in the PMN. The gene discussed is CCR2; the disease is neoplasm.