LIGHT-VTP, which consists of the TNF superfamily member LIGHT or TNFSF14 and a vascular targeting peptide (VTP) that specifically binds to angiogenic tumour vasculature, efficiently targets pathological blood vessels in the PMN, reducing vascular hyper-permeability and ECM deposition, thus blocking metastatic lung colonization [298]. The gene discussed is TNFSF14; the disease is neoplasm.