Epidermal growth factor receptor (EGFR), in exosomes secreted from gastric cancer cells, can be delivered into the pre-metastatic liver and is integrated on the plasma membrane of liver stromal cells including Kupffer cells and hStCs, which effectively triggers hepatotropic metastasis by facilitating the landing and proliferation of metastatic cancer cells [12]. The gene discussed is EGFR; the disease is gastric cancer.