Triple-negative breast cancer types can support their metastatic behaviour through modification of ECM proteins such as fibronectin, tenascin-c and periostin and soluble components including the metastasis-associated proteins CCL7, FGFR4, GM-CSF, MMP3, thrombospondin-1 and VEGF in the lung microenvironment [20]. Here, THBS1 is linked to breast cancer.