In in vitro and in vivo experiments performed in a mouse model of breast cancer, tumour-derived EVs incubated with the human-specific anti-CD9 or anti-CD63 antibodies were eliminated by macrophages, which significantly decreased metastasis to the lungs, lymph nodes, and thoracic cavity, although no obvious effects on primary xenograft tumour growth were observed [264]. This evidence concerns the gene CD9 and neoplasm.