As summarized in Table 1, R156H, A160T, V163G, R168H, P170S/L mutations located in T-loop of CDK5 with allele frequency of 0.1–0.42 were detected in tumor samples, and mutations R50W/Q, A48T and E50D were found in activators binding domain with allele frequency of 0.38–0.46, and G11W (allele frequency: 0.7) was mutated in ATP binding domain. Here, CDK5 is linked to neoplasm.