For example, the Ser202 phosphorylation of microtubule-associated protein Tau [63], the Ser522 phosphorylation of CRMP-2 (Collapsin Response Mediator Protein-2) [64] and the Ser16 phosphorylation of STMN1 (stathmin, microtubule decomposing protein) [65] are all CDK5 substrates that associated with carcinogenesis and tumor migration. This evidence concerns the gene DPYSL2 and neoplasm.