Senescence is frequently accompanied by senescence-associated phenotype (SASP) characterized by enhanced expression of several pro-inflammatory cytokines including IL-1, IL-6, CXCL8 and TGF-β1 [169] and indeed, senescent CML megakaryocytes expressed TGF-β1 in p16- and p21-dependent manner [164]. This evidence concerns the gene TGFB1 and chronic myelogenous leukemia, BCR-ABL1 positive.