Moreover, admixture with CCR1- or CCR5-deficient HSPCs blunted the leukemogenic ability of wild-type mouse-derived LSCs [152], suggesting that leukemia cell-derived CCL3 acts mainly on CCR1- or CCR5-expressing normal hematopoietic cells in bone marrow to promote leukemogenesis. This evidence concerns the gene CCR5 and leukemia.