Genomic instability predisposes to additional gene mutations, which are observed in BP-CML cells, such as p16 deletion [108], p53 loss of function [109], loss of retinoblastoma gene product [110], increased Evi-1 expression [111], or mutations in RUNX-1, ASXL1, and isocitrate dehydrogenases [112]. Here, RUNX1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.