ABL1 and leukemia: Moreover, the transduction of BCR-ABL gene conferred the capacities to self-renew in vitro and to cause leukemogenesis on murine HSCs but not HPCs [25] in contrast to acute myeloid leukemia models, where leukemia can develop upon the transduction into HPCs of oncogenic fusion genes such as the MLL-ENL [24] or the MOZ-TIF gene [25].