ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: When BCR-ABL gene was transduced into CCL3-deficient mouse-derived HSPCs to generate CML LSCs, the resultant LSCs induced CML development in irradiated hematopoiesis-incompetent mice but failed to do in un-irradiated hematopoiesis-competent mice, which preserved normal hematopoietic cells in bone marrow.