Our findings that bpV(pic) reduced the percentage of CD8+ T cells and suppressed inflammation in AT of DS/obese rats are consistent with the earlier finding that depletion of CD8+ T cells resulted in attenuation of M1 macrophage accumulation in visceral fat of mice with diet‐induced obesity (Nishimura et al., 2009). Here, CD8A is linked to obesity due to melanocortin 4 receptor deficiency.