We found that bpV(pic) ameliorated the restraint stress‐induced exacerbation of macrophage‐related inflammatory responses in AT of DS/obese rats in association with upregulation of IL‐10 production (likely from the increased proportion of B‐1 cells) and downregulation of inflammatory cytokine production (likely from the reduced proportions of both CD8+ T cells and B‐2 cells). Here, CD8A is linked to Dravet syndrome.