Consistently, we found that compared with those without TP53 mutations, TP53 mutation-positive tumor tissues harbored more Acidovorax as well as Massilia. It was demonstrated that TP53 mutation in lung cancer was attributed to direct DNA damage from cigarette smoke carcinogens (Pfeifer et al., 2002), and our results showed TP53 mutations were more prevalent in tobacco-related lung cancer. The gene discussed is TP53; the disease is neoplasm.