First, we should consider the fact that Kir6.2−/− mice have a complete deficiency of electrophysiological activity of the KATP channel in pancreatic beta cells and present neonatal transient hypoglycemia followed by normoglycemia with a partial reduction of glucose-stimulated insulin secretion (Miki et al., 1998). The gene discussed is KCNJ11; the disease is Hypoglycemia.